Selected publications
De novo Design of Quasisymmetric Two-Component Protein Cages
Wang, S.;* Xie, Y.; Chemielewski, D.; Weidle, C.; Hernandez, C.; Chen, W.; Ahn, G.; Duran, D.C.; Bera, A.K.; Bethel, N.; Decarreau, J.; Tong, S.; Kang, A.; Brackenbrough, E.; Joyce, E.; Lee, S.; Wu, K.; Borst, A.J.; Favor, A.; Huang, B.; DiMaio, F.; Holt, L.; Baker, D.*
2025. In revision @ Nature.
Design of One-Component Quasisymmetric Protein Nanocages
Lee, S.;†* Chemielewski, D.;† Wang, S.;† Kibler, R.; Park, Y.; Veesler, D.; Baker, D.*
2025. In revision @ Nature.
Bond-Centric Modular Design of Protein Assemblies
Wang, S.;* Favor, A.; Kibler, R.; Lubner, J.; Borst, A.; Coudray, N.; Redler, R.; Chiang, H.T.; Sheffler, W.; Hsia, Y.; Bethel, N. P.; Li, Z.; Ekeirt, D. C.; Bhabha, G.; Pozzo, L.; Baker, D.*
Top-Down Design of Protein Architectures with Reinforcement Learning
Lutz, I. D.;† Wang, S.;†* Norn, C.;† Courbet, A.; Borst, A.; Zhao, Y.T.; Dosey, A.; Cao, L.; Xu, J.; Leaf, E.M.; Treichel, C.; Litvicov, P.; Li, Z.; Goodson, A.D.; Rivera-Sanchez, P.; Bratovianu, A.; Baek, M.; King, N.P., Ruohola-Baker, H.; Baker, D.* (S.W. and I.D.L. author order was chosen arbitrarily)
Accurate Computational Design of Genetically Encoded 3D Protein Crystals
Li, Z.;† Wang, S.;† Nattermann, U.;† Bera, A.K.; Borst, J.A.; Bick, M.J.; Yang, E.C.; Sheffler, W.; Lee, B.; Nguyen, H.; Kan, A.; Dalal, R.; Lubner, J.M.; Hsia, Y.; Haddox, H.; Corbet, A.; Dowling, Q.; Favor, A.; Etemadi, A.; Edman, N.I.; Yang, W.; Sankaran, B.; Negahdari, B.; Baker, D.*
The Emergence of Valency in Colloidal Crystals through Electron Equivalents
Wang, S.;† Lee, S.;† Du, J. S.;† Partridge, B.; Cheng, H.; Zhou, W.; Das, A.; Dravid, V. P.; Lee, B. *; Glotzer, S.;* Mirkin, C. A.*
Colloidal Crystal Engineering with Metal-Organic Framework Nanoparticles and DNA
Wang, S.; Park, S.; Buru, C.; Lin, H.; Chen, P. C.; Roth, E. W.; Farha, O. K.; Mirkin, C. A.*
Particle Analogs of Electrons in Colloidal Crystals
Girard, M.;† Wang, S.;† Du, J. S.;† Das, A.;† Huang, Z.; Dravid. V. P.; Lee, B.; Mirkin, C. A.* Olvera de la Cruz, M.*
Review articles
Yang, W.;† Wang, S.;† Lee, G. R.;† Zhang, J.;† Courbet, A.; Juergens, D.; Wang, X.; Schlichthaerle, T.; Abedi, M.; Ragotte, R.; An, L.; Kalvet, I.; Pellock, S.; Mihaljevic, L.; Glasscock, C.; Pillai, A.; Broerman, A.; Ennist, N.; Haefner, E.; McNamara-Bordewick, N.; Haydon, I.; Stewart, L.; Bhardwaj, G.; Baker, D.* “The past, present and future of de novo protein design,” 2025. In revision @ Nature.
Wang, S.; Ben-Sasson, A.* “Precision Materials: Computational Design Methods of Accurate Protein Materials,” Curr. Opin. Struct. Biol. 2022. 74, 102367.
Wang, S.; McGuirk, C. M.; d’Aquino, A.; Mason, J. A.; Mirkin, C. A.* “Metal-Organic Framework Nanoparticles,” Adv. Mater. 2018, 30, 201800202.
Full publications
Huang, B.; Abedi, M.; Ahn, G.; Coventry, B.; Sappington, I.; Tang, C.; Wang, R.; Schlichthaerle, T.; Zhang, J. Z.; Wang, Y.; Goreshnik, I.; Chiu, C. W.; Chazin-Gray, A.; Chan, S.; Gerben, S.; Murray, A.; Wang, S.; O’Neill, J.; Yi, L.; Yeh, R.; Misquith, A.; Wolf, A.; Tomasovic, L. M.; Piraner, D. I.; Duran Gonzalez, M. J.; Bennett, N. R.; Venkatesh, P.; Ahlrichs, M.; Dobbins, C.; Yang, W.; Wang, X.; Sahtoe, D. D.; Vafeados, D.; Mout, R.; Shivaei, S.; Cao, L.; Carter, L.; Stewart, L.; Spangler, J. B.; Roybal, K. T.; Greisen, P. Jr.; Li, X.; Bernardes, G. J. L.; Bertozzi, C. R.; Baker, D. “Designed endocytosis-inducing proteins degrade targets and amplify signals,” Nature 2025, 638, 796–804.
Zhou, W.; Lim, Y.; Lin, H.; Lee, S.; Li, Y.; Huang, Z.; Du, J. S.; Lee, B.; Wang, S.; Sánchez-Iglesias, A.; Grzelczak, M.; Liz-Marzán, L. M.; Glotzer, S. C.; Mirkin, C. A. “Colloidal quasicrystals engineered with DNA,” Nat. Mater. 2024, 23, 424–428.
Ennist, N.; Wang, S.; Kennedy, M.; Curti, M.; Sutherland, G.; Vasilev, C.; Redler, R.; Maffeis, V.; Shareef, S.; Sica, A.; Hua, A.; Deshmukh, A.; Moyer, A.; Hicks, D.; Swartz, A.; Cacho, R.; Novy, N.; Bera, A.; Kang, A.; Sankaran, B.; Johnson, M.; Reppert, M.; Ekiert, D.; Bhabha, G.; Stewart, L.; Caram, J.; Stoddard, B.; Romero, E.; Hunter, C.N.; Baker, D.* “De novo design of proteins housing excitonically coupled chlorophyll special pairs,” Nat. Chem. Biol. 2024, 20, 906-915.
Said, M.;† Kang, C.;† Wang, S.;† Sheffler, W.; Salveson, P.J.; Bera, A.K.; Kang, A.; Nguyen, H.; Ballard, R.; Li, X.; Bai, H.; Stewart, L.; Levine, P.; Baker, D.* “Exploration of Structured Symmetric Cyclic Peptides as ligands for Metal-Organic Frameworks,” Chem. Mater. 2022, 34, 9736-9744.
Cheng, H.;† Wang, S.;† Mirkin, C. A.* “Electron Equivalent Valency Through Molecularly Well-defined Multivalent DNA,” J. Am. Chem. Soc. 2021, 143, 1752-1757.
Wang, S.; Du, J. S.; Dierks, N.; Zhou, W.; Roth, E. W.; Dravid, V. P.; Mirkin, C. A. “Colloidal Crystal ‘Alloys’,” J. Am. Chem. Soc. 2019, 141, 20443-20450.
Wang, S.;† Chen, Y.;† Wang, S.; Li, P.; Mirkin, C. A, Farha, O. K. “DNA-Functionalized Metal-Organic Framework Nanoparticles for Intracellular Delivery of Proteins,” J. Am. Chem. Soc. 2019, 141, 2215-2219.
Chen, P. C.; Liu, M.; Du, J. S; Meckes, B.; Wang, S.; Lin, H.; Dravid, V. P.; Wolverton, C.; Mirkin, C. A. “Interface and Heterostructure Design in Polyelemental Nanoparticles,” Science 2019, 363, 959-964.
Zhu, J.; Kim, Y.; Lin, H.; Wang, S.; Mirkin, C. A. “pH-Responsive Nanoparticle Superlattices with Tunable DNA Bonds,” J. Am. Chem. Soc. 2018,140, 5061-5064.
Wang, S.; Liao, Y.; Farha, O.; Xing, H.; Mirkin, C. A. “Electrostatic Purification of Mixed-Phase Metal-Organic Framework Nanoparticles,” Chem. Mater. 2018, 30, 4877-4881.
Wang, S.; McGuirk, C. M.; Ross, M.; Wang, S.; Chen, P. C.; Xing, H.; Liu, Y.: Mirkin, C. A. “General and Direct Method for Preparing Oligonucleotide-Functionalized Metal-Organic Framework Nanoparticles,” J. Am. Chem. Soc. 2017, 139, 9827-9830.
Morris, W.;† Wang, S.;† Cho, D.; Auyeung, E.; Li, P.; Farha, O. K..; Mirkin, C. A. “Role of Modulators in Controlling the Colloidal Stability and Polydispersity of the UiO-66 Metal-Organic Frameworks,” ACS Appl. Mater. Interfaces 2017, 9, 33413-33418.
Chen, P. C.; Liu, X.; Hedrick, J. L.; Xie, Z.; Wang, S.; Lin, Q. Y.; Hersam, M. C.; Dravid, V. P.; Mirkin, C. A. “Poly-Elemental Nanoparticle Libraries,” Science 2016, 352, 1565-1569.
Wang, S.;† Morris, W.;† Liu, Y.; Zhou, Y.; Hupp, J.; Farha, O.; Mirkin, C. A.* “External Surface-Specific Functionalization of Nanoscale Metal-Organic Frameworks,” Angew. Chem., Int. Ed. 2015, 54, 14378-14742.
Liu, D.; Wu, H.; Wang, S.; Xie, Z.; Li, J.; Lin, W. “A High Connectivity Metal–Organic Framework with Exceptional Hydrogen and Methane Uptake Capacities,” Chem. Sci. 2012, 3, 3032-3037.
Liu, D.; Kramer, A. S.; Huxford, R. C.; Wang, S.; Rocca, J. D.; Lin, W. “Coercing Bisphosphonates to Kill Cancer Cells with Nanoscale Coordination Polymers,” Chem. Commun. 2012, 48, 2668-2670.
Wang Lab 